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KMID : 0368820150540040482
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Journal of the Korean Neuropsychiatr Association
2015 Volume.54 No. 4 p.482 ~ p.488
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Alteration of Brain-Derived Neurotrophic Factor Levels in Panic Disorder
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이수아:Lee Soo-Ah
강남인:Kang Nam-In/이정훈:Lee Jeung-Hoon/김용구:Kim Yong-Ku/조홍자:Cao Hong Zi/이무석:Lee Moo-Suk/박종일:Park Jong-Il/박태원:Park Tae-Won/양종철:Yang Jong-Chul
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Abstract
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Objectives: Brain-derived neurotrophic factor (BDNF), a neurotrophin involved in neurogenesis and synaptic plasticity, has been implicated in the pathophysiology of several neuropsychiatric disorders. However, there have been no consistent findings regarding BDNF levels in panic disorder. In this study, we investigated plasma BDNF levels in panic disorder, and evaluated whether there is an association between plasma BDNF levels and severity of symptoms of panic disorder.
Methods: Plasma BDNF levels were measured in 110 panic disorder patients and 110 normal control subjects using the enzyme-linked immunosorbent assay. The severity of symptoms of panic disorder was determined using the Panic Disorder Severity Scale, Acute Panic Inventory, Agoraphobic Cognition Questionnaire, and Hamilton Anxiety Rating Scale.
Results: The mean plasma BDNF levels of patients with panic disorder were significantly lower compared with those of control subjects (192.50 pg/mL vs. 693.75 pg/mL). No significant association was observed between plasma BDNF levels and the severity of symptoms of panic disorder.
Conclusion: These results suggest that BDNF may play a potential role in the pathophysiology of panic disorder.
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KEYWORD
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BDNF, Neurotrophin, Panic disorder
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